Naomi Osaka has pulled out of the Wimbledon championship
Roger Federer regretted easing the pressure on Rafael Nadal after the first set of the French Open final
While Mahesh Bhupathi suffered disappointment in the doubles as well as mixed doubles
Frenchman Paul-Henri Mathieu gave the defending champion a nasty 20th birthday fright before the Spaniard prevailed 5-7, 6-4, 6-4, 6-4.
Leander Paes entered the second round, while Sania Mirza bowed out of the mixed doubles at the French Open.
Rafael Nadal will have to contend with more than 15,000 fans determined to ruin his 20th birthday celebrations when he faces the French hope on Saturday.
The Russian was fined the maximum $10,000 for refusing to attend a news conference after his first round defeat at the French Open.
The Swiss has never been beyond the semi-finals at Roland Garros.
Andy Roddick and Nadia Petrova made first round exits at the French Open on Tuesday
Rafael Nadal believes Roger Federer can beat him anytime on any surface
The Indian ace will meet former champion Anatasia Myskina in her opening match in the women's singles.
It will be the second time Nadal and Del Potro meet at Roland Garros. The previous match up saw the Spaniard beat Del Potro in straight sets in the opening round in 2007.
American Williams, seeded 10th and competing in her 20th French Open, powered 22 winners and converted six of 13 break points as she picked apart the 60th-ranked Belgian in just over an hour.
World number three Stanislas Wawrinka stormed back from a set down to beat German qualifier Mischa Zverev 4-6, 6-3, 6-3 and retain the men's title in Geneva on Saturday.
The unseeded Indian pair registered a comfortable 6-4, 6-2 victory over Phillip Simmonds of the United States and Fritz Wolmarans of South Africa.
Justine Henin-Hardenne returns to the court where she won her first grand slam on Monday.
When the French Open begins on Monday, not only will Roger Federer stand apart, but he will start as favourite to win the title.
The world number two she has to give her wrist more time to recover from a recurrent injury.
Federer decided to end his Roland Garros campaign on Sunday, a day after winning a gruelling third-round match against Dominik Koepfer.
The world number two is worried she will not be fit enough to give her best in next month's French Open championships.
Images from Day 11 of the 2021 French Open at Roland Garros in Paris on Wednesday.
Zverev had surgery on torn ligaments in his right ankle this month after he was forced to retire from his French Open semi-final against Rafael Nadal.
The Argentine said there is no truth in a report in a French newspaper that he had tested positive at the 2005 French Open.
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